From the album - Lost Highway is the title of the tenth studio album by Bon Jovi. Described by Jon Bon Jovi as "a Bon Jovi album influenced by Nashville", the album influences the band's rock sound with that of country music following the success of a country version of the band's 2006 single "Who Says You Can't Go Home", a duet with Jennifer Nettles, which reached #1 on the U.S. country chart in May 2006.

Following the success had with the duet version of "Who Says You Can't Go Home", there are two songs on the album produced in collaboration with other artists, namely "We Got It Going On" featuring Big & Rich and "Till We Ain't Strangers Anymore" featuring LeAnn Rimes.

The album debuted at #1 on the Billboard 200, becoming Bon Jovi's first ever album to debut at #1 and their third album to reach that position after Slippery When Wet in 1986 and New Jersey in 1988.[2] The album also debuted at #1 in Japan. This is the fourth such time, breaking the Beatles record of having three number one albums in the country.

The album was nominated for Best Pop Vocal Album at the 2008 Grammy Awards.